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Our range of Dextrans for research
Aug 11, 2016

Dextran is a complex branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 5 to 2000 kilodaltons). It is used medicinally as an antithrombotic (antiplatelet), to reduce blood viscosity, and as a volume expander in hypovolaemia.

Range of Dextran products (click)

The straight chain consists of α-1,6 glycosidic linkages between glucose molecules, while branches begin from α-1,3 linkages. Dextran is synthesized from sucrose by certain lactic acid bacteria, the best-known being Leuconostoc mesenteroides and Streptococcus mutans. Dental plaque is rich in dextrans.

Typical Laboratory uses

- Dextran is used in the osmotic stress technique for applying osmotic pressure to biological molecules.

- It is also used in some size-exclusion chromatography matrices.

- Dextran has also been used in bead form to aid in bioreactor applications.

- Dextran has been used in immobilization in biosensors.

- Dextran preferentially binds to early endosomes, fluorescent-labelled dextran can be used to visualize these endosomes under a fluorescent microscope.

- Dextran can be used as a stabilizing coating to protect metal nanoparticles from oxidation and improve biocompatibility.

- Dextran coupled with a fluorescent molecule such as fluorescein isothiocyanate can be used to create concentration gradients of diffusible molecules for imaging and allow subsequent characterization of gradient slope.

- Dextran is used to make microcarriers for industrial cell culture.

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