Appearance (Colour)
White to pale yellow
Appearance (Form)
Powder
Solubility (Turbidity) 10% aq. solution
Clear
Solubility (Colour) 10% aq. solution
Colourless to pale yellow
Assay (NT)
min. 98.0%
Melting Point
178 - 182°C
Loss on drying
max. 0.5%
Application
Adipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
